Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) most commonly includes liver and skin. However, drug reactions can rarely influence both organs concomitantly. Further studies are required to determine clinical features, risk factors, and prognostic markers of drug-induced liver injury (DILI) in patients with SJS/TEN. 

The present review assessed the clinical features, risk factors, and prognostic markers of DILI in patients with SJS/TEN hospitalized at the dermatology department of our hospital from January 2009 to December 2018.

Thus, the trial concluded that DILI is a common finding in patients with SJS/TEN. The important risk factors for DILI in patients with SJS/TEN include pre-existing liver disease, diabetes, and hyperlipidemia. Furthermore, high serum total bilirubin and creatinine levels can act as potent prognostic markers for DILI in patients with SJS/TEN.

Source: Indian J Dermatol. 2020;65(4):274-278.